The patient did not require additional treatment. The International Federation of Gynecology and Obstetrics staging was IA. The pathological findings were adult-type granulosa cell tumor. We finally performed right salpingo-oophorectomy, endometrial biopsy, peritoneal biopsy, and partial omentectomy. The tissue stained positive for inhibin-α, Wilms' tumor-1, CD56, and negative for cytokeratin 7. The pathologic findings showed an adult-type granulosa cell tumor with necrosis and hemorrhage. She had been taking dienogest 2 mg for 2 years for a misdiagnosed endometrioma, but over a 2-year course, the mass increased to 50 mm.Īn ultrasound scan revealed a 47 × 37-mm round solid mass in the right ovary with a spongiform appearance and little vascularity. GCTs usually present with features of hyperestrogenism, with an average size is 10 to 15 cm.Ī 31-year-old nulligravida diagnosed with polycystic ovarian syndrome (PCOS) 10 years prior, had a 20-mm mass in her right ovary found on ultrasonography 2 years ago. Granulosa cell tumors (GCTs) account for less than 2% of all ovarian malignancies and are the second most common ovarian sex cord stromal tumors after fibroma/thecomas.GCTs occur most frequently in postmenopausal women with a peak age of 50 to 55, are usually diagnosed in their early stages, and have a good prognosis. Besides, gynecologists should comply with the tumor-free principle during surgery. However, laparoscopic surgery is still an optimal treatment strategy for ovarian tumors. The application of LPM may be a risk factor of disseminated ovarian GCT. The 2 patients presented disease-free survival for more than 33 months follow-up period. The postoperative pathologies of both case 1 and case 2 reported ovarian GCT (IIIc stage) in adult type. Numerous malignant metastasis neoplasms were detected at the port-sites. ![]() Subsequently, they received a repeated operation through a laparotomy approach. They experienced relapsed ovarian GCT postoperatively. The 2 patients had a medical history of surgery for ovarian GCT by using laparoscopic with power morcellators (LPM). The 2 patients presented with abdominal pain.īoth the patients were diagnosed with relapsed ovarian GCT (IIIc stage) in the adult type. Herein, this report aims to present 2 rare cases of disseminated ovarian GCT and analyze the causes of recurrence. Short-term relapsed ovarian GCT is extremely rare. Granulosa cell tumors (GCT) have an incidence of 0.6 to 0.8/100,000.
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